Tana grew up in Hawaii, but after college decided to move to Metropolis. She applied for a job at the The Daily Planet, but Perry White was not particularly impressed with the young woman and considered her "still in school." He did offer her an assignment covering a bake off to show what she could do. However, as she was leaving the building, she met the new Superboy, who had just arrived in Metropolis following the Death of Superman. Tana brought the Kid to GBS, which gave her a job as a news anchor, allowing her to cover from a helicopter the Kid's battle against a local hood named Steelhand. GBS President Vinnie Edge arranged for a supervillain, Stinger, to attack the Kid next so as to have higher ratings, and Tana covered the even from her helicopter (she realized during the battle, when the Stinger collapsed the Hobsneck Bridge, that Vinnie had set the whole thing up. After Coast City was destroyed, Superboy was asked to investigate the destruction along with the Cyborg Superman. Tana wanted to be sent over to cover the boy, but Vinnie refused to send her, telling her that the Kid is what matters, not her. Tana remained in Metropolis and was reporting live when Engine City launched a missile at the city, aimed at destroying it and building a second Engine. Superboy deflected the missile, which exploded over the bay, and Tana broke down in tears on the air at the thought of Superboy having been killed (which, of course, he was not). After the real Superman returned, Tana decided to quit her job and leave Metropolis. She informed the Kid of her decision, but did not really explain why at the time. Superboy was shocked, since he considered her to be one of his only friends.
Tana had decided to move back home to Hawaii, where she quickly got a job as a television reporter there. As luck would have it, Superboy soon turned up there, as part of his World Tour, and decided to stay put (his reason for staying was motivated in part by Tana's presence).
At first, Tana maintained a friendly but professional attitude towards Superboy. But when the Kid was dying of the Clone Plague, she expressed her true feelings for the Kid. When he returned to Hawaii alive and well, the two entered into a romantic relationship, despite the apparent age difference and the corresponding remarks it generated. It earned her the enmity of Roxy Leech, who saw Tana as the only thing between her and a relationship with Superboy.
Superboy and Tana maintained their romantic and professional relationship. However, when Knockout arrived at the Kid's doorstep, announcing her intention to partner up with him, their relationship was turned upside down. While the Kid insisted at first that he and Knockout were only friends and that Tana was his gal, Tana had her doubts about Knockout. She decided to do some investigating, which lead her to the strip club where Knockout worked. She was not there long, however, before the Female Furies turned up, tipped off by recent newscasts of their "lost sister," leading to an all out brawl between Superboy, Knockout, and some police officers on one side and the whole team of the Furies on the other. The Furies were only driven off with some help from Dubbilex, but in the fighting a police officer was struck down by Knockout when he got in her way. Despite the evidence against her, Superboy refused to believe she was guilty, and when Tana tried to reason with her he got upset and broke up with her. Knockout soon revealed her true colors, however, and Superboy brought her in.
In the fallout, Superboy had a talk with Tana, and she quickly took him back. At the same time, she gave an interview to Amanda Spence, unwittingly supplying her with crucial information which the Agenda then used to apprehend the Kid. Luckily, Superboy managed to escape from the Agenda's clutches and return safely to Hawaii. They had infected him with a virus, however, that quickly began to break down SB's DNA. He had to be rushed back to Cadmus, where a cure was found using Roxy as a donor. Tana was worried that this would mean SB would leave her for Roxy, but Superboy and Roxy both agreed that after the process they felt more like siblings than anything else, so Tana got to keep the Kid.
Unfortunately, the results of Superboy's cure left him locked at the age of sixteen, and Tana felt that he began to act more and more immature. This culminated in his flirtatious attitude with members of the Legion of Superheroes which were broadcast on television. When she finally had enough, Tana broke up with Superboy. She left Hawaii on a job shortly thereafter, right when Superboy had gone missing after a failed publicity stunt.
It would turn up later that Tana was subsequently captured by the Agenda, but the Wild Men were able to rescue her and arrived at Cadmus after the Agenda had taken it over. Superboy was overjoyed to be reunited with Tana -- but the joy would be short lived. Superboy and his allies had retaken Cadmus, defeated the Agenda, and thanks to a spell by Klarion the "Kid" was temporarily aged to adulthood. Yet Amanda Spence would have her. Just before escaping, she brutally murdered Tana right before Superboy's eyes. Superboy was devastated by the loss.
Later Superboy encountered the DNAngels, Cherub, who not only have the mixed DNA of members of Young Justice, but also of Tana. It turns out that Amanda Spence made her so she can have the pleasure of killing Tana over and over again.