Kara Zor-El was born to Zor-El, Jor-El's older brother and husband to Alura In-Ze. Although Zor-El didn't get along with his brother, he paid heed to his warnings about the impeding destruction of the planet, and decided to save his daughter by sending her to the same place his Jor-El planned to send his son.
Last Daughter of Krypton
Kara Zor-El's pod from Krypton crash landed in Russia. She stumbled from her craft only to be suddenly surrounded by gigantic armed robots who began trying to subdue her. She fought bravely, learning about her incredible powers for first time, until she was finally overcome by the robots and her own confusion of being on a distant unknown planet. With a blaster pointed to the back of her head she was finally saved by nothing less than a single word from Superman.
Confused by her current situation and her new powers, Kara angrily demanded to know why Superman was wearing her family's crest. When Superman identified himself as her cousin Kal-El, Kara became enraged, thinking he was an impostor; in her mind she was holding baby Kal-El only the day before. Kara attacked Superman, only to become scared by her own new abilities, such as x-ray vision and flight. The two exchanged blows all the way from Siberia to the Great Wall of China. After punching Superman through the Great Wall, Kara realized her fight was endangering the people nearby and agreed to stop fighting and listen to Superman.
When Kara flied back to Siberia to search for the capsule, she was invited by Symon Tycho to his space station, where he tested her abilities and limits. Finally, he watched her being weakened by green Kryptonite and captured her in a tank near from a chunk of green Kryptonite.
However, an employee of Tycho helped Kara break out. Still not in the full control over her powers, Kara accidentally seemed to destroy the whole space-station.
However, Kara managed to save a Sunstone that Tycho stole from her pod. Unfortunately, it was too damaged to provide answers. Kara despaired of finding answers to her predicament and wondered if her new powers would allow her to fly back Krypton.
Kara left Earth, heading for her home-world. On the way, the sunstone helped her find a spatial portal which took her back to her hometown Argo City, now a deserted city protected by a bubble shield and orbiting a blue star. Exploring the ruins, Kara finally confirmed that Krypton was gone and her family and friends dead. Overwhelmed by grief and fury, she cried out and started to tear the city up. Her rampage was stopped by a mysterious woman named Reign, who claimed to be a worldkiller (a superpowerful, sentient biological Kryptonian weapon). They fought but Reign defeated her easily, pinning her to a wall and leaving, challenging Kara to follow her back to Earth.
Emboldened by her parents' memories, and summoning all the strength she had left, Kara managed to break free and fly back to Earth, in where Reign and three more Worldkillers (Flower of Heaven, Perrilus, and Deimax) were leveling New York.
After a tough, exhausting battle Kara won against all odds, beating the worldkillers back. Before leaving, though, Reign warned Kara that she would return one day... and her father, Zor-El, made five Worldkillers originally, not just four.
Meeting Silver Banshee and Superboy
Right after the battle Kara met Siobhan Smythe, an Irish girl with a gift for language and music. Both girls befriended each other quickly, and Siobhan offered to help Kara, leaving her staying in her apartment for a while until her Kryptonian friend was ready to face her new world.
Siobhan decided to bring Kara to listen to music at a club. While at the club, both girls were attacked by Siobhan's father, a villain known as Garrett McDougal (Black Banshee). Being a magic creature, Black Banshee hurt Kara, forcing Siobhan to transform into Silver Banshee in order to stop him.
Working together, Kara and Siobhan defeated Black Banshee and rescued Thomas, Siobhan's big brother who had been previously absorbed by Black Banshee.
A while later Kara met Kon-El (Superboy) when she was taking some time by herself. They talked, but when she learnt about him being a clone, she attacked, believing him to be evil. However she stopped her attack when she realized that Superboy didn't know that Kryptonian clones were mindless killing machines. Seeing Superboy wasn't evil, Kara protected him from a police attack and opted to leave him alone, going to confront Kal about Kon.
Upon arriving on Metropolis, Kara had to battle a Superman duplicate to protect the city. Kara fought valiantly, but the fake Superman gained the upper hand and beat Kara up. Their battle got interrupted when the real Superman showed up and managed to defeat the imposter. Kara congratulated her cousin and questioned him about Superboy, but Kal explained he didn't know anything about Superboy.
While having lunch with Tom Smythe at a cafe, Kara was attacked by a humanoid blob. She fought and won, but the fact that thing was able to find her when she was dressed in plain clothes worried her. Kara left Siobhan and Tom for their own safety and to find out who was attacking her.
Kara brought the remains of her attacker to Kal-El, and using the technology in his Fortress of Solitude, they tracked the signal that was controlling the nano-machine man back to its source, miles beneath the ocean. Superman offered his assistance, but Kara still didn't fully trust him, and after turning down his offer to help yet again, she left to find whoever was attacking her.
Exploring the ocean floor, Kara found a Kryptonian sanctuary, created by a fragment of her pod. She also found out Simon Tycho had invaded her Sanctuary of Solitude and was the one was behind the attacks. Kara battled him and locked him away in a crystal prison, claiming her underwater base.
H'el on Earth
During the events of "Hel on Earth", H'el tricked Kara into helping him, promising to save Krypton and claiming that Earth would not suffer. Kara helped him, even going so far as to battle her cousin, Superboy, the Flash and Wonder Woman, until she found out that H'el actually planned to destroy Earth to bring Krypton back. Horrified, Kara turned against him. During the final battle, she stabbed him in the chest with a shard of Kryptonite, saving the planet.
Kara collapsed afterwards, muttering that she couldn't "leave things to her baby cousin". Superman held her in her arms as he carried her to safety.
Supergirl and Power Girl
Her ordeal with H'el left Kara with a severe case of Kryptonite poisoning.
Kara went to Dr. Shay Veritas to help, but she grew impatient and left during a battery of tests. On her way back, Kara was attacked by an alien woman made of lava  (who previously had attacked Superboy ). The lava woman defeated Kara, but she fled when the US Army came along. The soldiers were about to an unconscious Kara with them, when Power Girl showed up and rescued her alternate self.
Both girls fought the army and an agent of Lex Luthor named Appex. Supergirl and Power Girl won the battle, but Kara fainted again, and Power Girl took her to Sanctuary to heal her. Unfortunately, the Sanctuary's AI went crazy and tried to kill Kara, forcing both heroines to blow it up.
I'noxia and Cyborg Superman
Believing that no one could heal her illness, Kara left Earth to die alone.
Kara headed out into space and ran into I'noxia, a technological world conquered by Brainiac and ruled by Cyborg Superman.
Cyborg Superman pretended to be a friend before revealing his true intentions: using Kara's flesh to reconstitute his own body and restore his memory. Kara fought hard and desperately but he won. Kara's body was dissolved and her soul was forcefully integrated into the I'noxian mind-hive as her flesh was used to reconstruct Cyborg Superman's body. However Cyborg Superman got his memories back and remembered he was Kara's father.
Horrified, Zor-El rebuilt Kara's body -who was meanwhile tearing down the I'noxian's collective consciousness-, turning himself back into the Cyborg Superman. While he and Brainiac -who had come to check on his pawn- fought, Supergirl and the I'noxian collective escaped undetected.
Kara helped Superman and Superboy to ruin Hel's plans to bring Krypton back to life, an act which would alter the timeline and destroy the universe.
Supergirl travelled to the Battle of the Sky Core during the Great War in order to prevent a clone insurrection, and defeated H'el in that timeline. For his part, Superboy was sent to Argo City, a few days before Krypton's destruction, and protected Kara Zor-El from H'El.
Kara and Kal reunited in the present after fulfilling their respective missions. There, they learnt Superboy didn't make it. Mourning his loss, they returned to Earth.
Red Daughter of Krypton
After several months of endless battles during which Kara never dealt with her survivor guilt and feelings of loss and loneliness, and believing she had been manipulated, betrayed or let down by everybody she met, Kara was on the verge of a breakdown.
While visiting Dr. Veritas, Kara ran into Lobo.. They fought, and during the battle Lobo taunted Kara until she exploded, and her long-repressed, unleashed fury acted like a magnet to a Red Power Ring.
After a brief scuffle with Silver Banshee, a barely coherent and enraged Kara flew into space so that she didn't hurt anybody. Found by a pair of Green Lanterns, Kara was taken to Ysmault by Hal Jordan  and dunked into the Blood Ocean. After getting her sanity back, Kara joined the Red Lantern Corps of Guy Gardner. 
Ironically, joining the Rage Lanterns helped Kara get over her anger and isolation issues, and gain emotional stability. She fought alongside the Red Lanterns for a while, battling the Diasporans  and Atrocitus splinter cell  until Guy kicked her out of the team so she didn't die while fighting Atrocitus.
While Kara was returning to Earth, she was attacked by the Diasporan army, who tried to capture her. Kara beat them and engaged the Diasporan leader, who revealed he was the last Worldkiller. A parasitic being, the Worldkiller tried to bond with Kara and take over her body. Kara hurled herself into the Sun to destroy it, but when her attempt failed, she removed her Red Ring. Such an action should kill her, but the Sun restarted her heart and granted her a power boost which allowed her to destroy the last Worldkiller once and for all.
Free from the Red Ring and the accompanying all-consuming anger and confusion clouding her mind, Kara realized Earth could become her new home after all, and headed for the planet.
During the events of Superman Doomed, Kara and her Red Lantern allies tried to stop the infected Superman, but Kal-El  defeated them easily. So she tried a different tactic, showing her cousin he could harness his anger to protect the galaxy, like she had done.
After ridding herself of the Red Ring, Kara returned to Earth and helped out to rescue people trapped or hurt owing to the energy-draining Brainiac's attack. In the process she saved the parents of Michael, a crippled boy she had a brief relationship with.
Shortly after she spotted Superman when he was returning to Earth and caught him when he got hit by an energy pulse that sent him plummeting through the atmosphere. Finally, Kara saved Batman from Cyborg Superman, defeating him conclusively.
In the aftermath of the battle against Brainiac, Kara met Jason Todd (Red Hood), who 'requested' her help to dismantle an alien gang that was supplying alien weaponry to street gangs.
Red Lantern Atrocities
Shortly after Kara left the Red Lanterns, Atrocitus invaded Earth. Kara took part in the battle, helping her ex-team out  and keeping an army of newly-created Red Lanterns at bay while Guy took the fight to Atrocitus.
Remarkably, she had the opportunity to seize a new Red Ring but she turned it down, arguing that she had let her anger go.
During the Future's End event, Cyborg Superman erased Kara's memories and turned her into Cyborg Supergirl, turning her into his tool with which find a world he could transform into a New Krypton. Four years later, the duo ran into the Wanderers, who managed to undo Cyborg Superman's mind-wipe. Horrified, Kara turned against Cyborg Superman -yet not knowing his real identity- and fought him. Afterwards she joined the Wanderers.
Supergirl and the Justice League
After being released from the Red Ring, Supergirl joined the Justice League United team along with (Martian Manhunter), (Stargirl), (Green Arrow), (Animal Man), (Hawkman), Equiniox, (Adam Strange) and (Alanna Strange).
While several alternate Supergirls fought in the Convergence planet, Kara joined the heroes working to save the universe. However, when Telos manifested in their universe, most of heroes fled. Only Kal and Kara stayed behind to watch, holding hands and hoping for the best.
After her ordeal with the Red Lanterns, Super-Doom and Brainiac, Kara decided to make an effort to adapt to Earth. She started working as barista in New York and dated Michael. During a heart-to-heart conversation with her cousin, she stated that Earth was her home now and she wanted to live among the people she was protecting.
Shortly later she was transported away to Crucible Academy, an intergalactic organization that trains heroes. Kara agreed to undergo training, and after helping to uncover a conspiracy to take over the school, she graduated and returned to Earth.
After returning, though, she realized her powers were suddenly gone.
Final Days of Superman
After coming back from Crucible Academy, Kara's powers started being leeched by Vandal Savage shortly before her cousin's secret identity was revealed during the "Truth" storyline.
She still tried to help people until she lost most of her powers. Then she was approached by Director Cameron Chase, who offered to help her get her powers back if Kara joined the Department of Extranormal Operations (D.E.O.). Kara agreed, leaving New York City and the Justice League with no explanation and moving to National City.
A few weeks later Superman sought Supergirl out to reveal he was dying, tell her his Fortress belonged to her now and ask her to consider protecting Earth after he was gone. Shedding a tear, Kara accepted.
Later, while she was undergoing treatment to restore her powers, Kara heard her cousin was in danger. She told her new foster parents to let her go, and streaked off. Kara joined the battle against the Denny Swan (the Energy Superman), and learned from the existence of the Pre-Flashpoint Superman, but she was unable to save her cousin. Before his death, she vowed that she would make him proud.
As a last-ditch effort to restore her powers, the D.E.O. built a space rocket and sent Kara into the Sun. The intense charge of solar energy managed restore Supergirl's powers, and she flew back to Earth just in time to save the D.E.O. from a Kryptonian werewolf called Lar-On who escaped from the Phantom Zone accidentally.
After that ordeal Kara started working for the D.E.O. officially, moving to National City, being adopted by Jeremiah and Eliza Danvers and attending her new school.
Reign of the Cyborg Supermen
While Kara tried to adapt to her new life and new parents after her cousin's death, Cyborg Superman returned, revealing his true identity to Kara and vowing to make her happy by bringing Argo City back to life... even if he had to sacrifice Earth in the process. He refused to listen when Kara tried to dissuade him from that course of action, forcing her daughter to fight him. Kara managed to disable his cybernetic body, and after expressing regret at his inability to ask her help to save Argo, Kara hugged him and vowed to help him go back to being the man he was.
- ↑ Supergirl Vol 6 #1
- ↑ Supergirl Vol 6 #2
- ↑ Supergirl Vol 6 #3
- ↑ Supergirl Vol 6 #4
- ↑ Supergirl Vol 6 #5
- ↑ Supergirl Vol 6 #6
- ↑ Supergirl Vol 6 #7
- ↑ Supergirl Vol 6 #8
- ↑ Superboy Vol 6 #6
- ↑ Superman Vol 3 #6
- ↑ Supergirl Vol 6 #11
- ↑ Supergirl Vol 6 #12
- ↑ Supergirl Vol 6 #13
- ↑ Superman Vol 3 #17
- ↑ Supergirl Vol 6 #18
- ↑ Superboy Vol 6 #3
- ↑ Supergirl Vol 6 #19
- ↑ Supergirl Vol 6 #20
- ↑ Supergirl Vol 6 #21
- ↑ Supergirl Vol 6 #22
- ↑ Supergirl Vol 6 #23
- ↑ Supergirl Vol 6 #24
- ↑ Action Comics Annual Vol 2 #2
- ↑ Supergirl Vol 6 #25
- ↑ Superboy Vol 6 #25
- ↑ Superman Vol 3 #25
- ↑ Supergirl Vol 6 #26
- ↑ Supergirl Vol 6 #27
- ↑ Supergirl Vol 6 #28
- ↑ Supergirl Vol 6 #29
- ↑ Green Lantern Vol 5 28
- ↑ Red Lanterns Vol 1 28
- ↑ Supergirl Vol 6 #30
- ↑ Supergirl Vol 6 #31
- ↑ Red Lanterns Vol 1 #32
- ↑ Supergirl Vol 6 #32
- ↑ Supergirl Vol 6 #33
- ↑ Superman/Wonder Woman Vol 1 #9
- ↑ Action Comics Vol 2 #33
- ↑ Supergirl Vol 6 #34
- ↑ Action Comics Vol 2 #35
- ↑ Superman: Doomed Vol 1 #2
- ↑ Supergirl Vol 6 #35
- ↑ Red Lanterns Annual Vol 1 #1
- ↑ Red Lanterns Vol 1 #34
- ↑ Supergirl: Futures End Vol 1 #1
- ↑ Convergence Vol 1 #8
- ↑ Supergirl Vol 6 #36
- ↑ Supergirl Vol 6 #40
- ↑ Justice League United Vol 1 11
- ↑ Action Comics Vol 2 #51
- ↑ Superman/Wonder Woman Vol 1 #29
- ↑ Superman Vol 3 #52
- ↑ Supergirl: Rebirth Vol 1 #1
- ↑ Supergirl Vol 7 #1
- ↑ Supergirl Vol 7 #3
- ↑ Supergirl Vol 7 #5
- ↑ Supergirl Vol 7 #6