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The Society for International Space Exploration (SISE) is an agency consisting of American astronauts and Soviet cosmonauts.
In Superman II, a SISE moon mission is in its 45th day when the crew of the Artemis II is attacked by General Zod, Ursa and Non. While in contact with mission control, lunar module pilot Nate reports the appearance of an unidentified flying object. Outside the lander, Andy and Boris are attacked and killed by the Kryptonians.