The H.I.V.E. Queen was one of The Twenty who were modified by Brainiac during his first attack on Metropolis. Like the others, she gained psionic powers. She was also seeded with Brainiac's mission in her mind, and unlike the others, she became a true believer. She founded H.I.V.E., with the purpose of psionically uniting humanity as part of a hive mind in preparation for Brainiac's return. To this end, she captured the Twenty, as well as any other being with psionic powers.
She was overthrown, however, when she captured Hector Hammond, who was able to take over H.I.V.E. from her. (Superman: "Psi War")